Explore Dual-PhD carrier research, patent-pending modified-chitosan delivery, and 4 flexible cosmetic ODM tracks.
In vivo dual-labeled skin fluorescence microscopy (+190% at 2h, +260% at 8h, p < 0.001) complementing +494.44% 4h ex vivo porcine Raman permeation.
In vivo dual-labeled skin fluorescence microscopy (+190% at 2h, +260% at 8h, p < 0.001) complementing +494.44% 4h ex vivo porcine Raman permeation.
WUMO PDRN+™ Transdermal Chitosan-PDRN Complex (6:1 HCS@PDRN)
Electrostatic 6:1 hydroxyethyl-chitosan self-assembled transdermal salmon DNA (Sodium DNA / PDRN) delivery system compressing 539.5 nm free PDRN (PDI 0.53) into monodisperse 188.0 ± 4.32 nm nanospheres (PDI 0.14). Verified +494.44% 4-hour ex vivo porcine skin Raman permeation and +260% 8-hour in vivo dermal fluorescence.
+494.44% 4h ex vivo porcine skin Raman permeation (~6× faster barrier entry)539.5 nm (PDI 0.53) → 188.0 ± 4.32 nm (PDI 0.14) monodisperse 6:1 co-assembly+260% 8h in vivo dermal fluorescence (p < 0.001) & macropinocytosis uptakeHaCaT IL-6 -33.13%, 24h scratch closure -34.23% & DNFB epidermal relief -52.26% vs. free PDRN
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- Check typical applications and document availability
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Direct Answer
Ingredient identity for buyer review
Confirm naming, CAS, document scope, and inquiry intent before sample, MOQ, lead-time, or bulk quotation discussion.
- Market Name
- WUMO PDRN+™ (6:1 HCS@PDRN Self-Assembled Transdermal PDRN System)
- INCI Name
- Water, Sodium DNA, Hydroxyethyl Chitosan, 1,2-Pentanediol, Hydroxyacetophenone (or Butylene Glycol, Water, Hydroxyethyl Chitosan + Sodium DNA)
- Synonym
- Hydroxyethyl Chitosan Co-Assembled Salmon DNA (Oncorhynchus mykiss / Oncorhynchus keta) Complex
- Common Review Documents
- TDS, Batch COA, % INCI Breakdown, 16-Section GHS SDS, Preclinical Raman & DLS Summary
- Buyer Intent
- Transdermal salmon DNA serums, clear-turning hydrogel masks, dual-phase capsule creams, and clinic soothing SKUs
Specifications
Specifications
Review the core data firstCheck the technical points buyers usually confirm before pricing or sample discussion.
Market NameWUMO PDRN+™ (6:1 HCS@PDRN Self-Assembled Transdermal PDRN System)
INCI NameWater, Sodium DNA, Hydroxyethyl Chitosan, 1,2-Pentanediol, Hydroxyacetophenone (or Butylene Glycol, Water, Hydroxyethyl Chitosan + Sodium DNA)
SynonymHydroxyethyl Chitosan Co-Assembled Salmon DNA (Oncorhynchus mykiss / Oncorhynchus keta) Complex
AppearanceClear to slightly opalescent aqueous nanocarrier dispersion
Hydrodynamic Diameter (DLS)188.0 ± 4.32 nm at 6:1 HCS:PDRN ratio (vs. 539.5 ± 20.42 nm free PDRN)
Polydispersity & Zeta PotentialPDI 0.14 ± 0.01 (monodisperse) · Zeta -16.1 ± 3.64 mV (vs. -32.9 ± 5.18 mV free PDRN)
Applicable Formula pHpH 5.0 – 8.0 (add during cool-down phase ≤45 °C)
Reference ODM DosingSmart carrier target e.g. 200 ppm – 500 ppm co-assembled PDRN equivalent (customized per serum, hydrogel mask, or capsule cream)
Common Review DocumentsTDS, Batch COA, % INCI Breakdown, 16-Section GHS SDS, Preclinical Raman & DLS Summary
Buyer IntentTransdermal salmon DNA serums, clear-turning hydrogel masks, dual-phase capsule creams, and clinic soothing SKUs
+219% 8-hour ex-vivo skin permeation, -32.0% ACh inhibition at 1/10th dose, and GQI 33-subject trial data.
Inspect on-site booth photos, ISO 22716:2007 cosmetic GMP certificate, and buyer Q&A from Guangzhou.
Typical Applications
Typical Applications
- One-step clear-turning salmon DNA & pro-peptide hydrogel masks
- Dual-phase suspended peptide & nano-PDRN capsule creams
- Post-facial / aesthetic clinic soothing & barrier-recovery essences (intact-skin cosmetic scope)
- Neck, eye-contour, and anti-photoaging firming emulsions
MOQ / Lead Time / Samples
Commercial follow-up usually starts here.
- Sample availability can be confirmed for qualified projects
- MOQ and lead time are shared during inquiry
- Pricing and file requests can be handled together
Why buyers trust WUMO
Real content, documented — not guesswork
In peptide sourcing, chromatographic purity and delivered quantity require separate evaluation. We keep purity and labeling basis distinct on available documentation, so buyers can review analytical parameters for their quoted batch before ordering.
Purity vs quantity distinction
Purity (%) and reported quantity are distinct analytical parameters. Review purity and reported quantity separately, and confirm the labeling and assay basis for the batch proposed for your order.
Batch-specific documents
Batch documentation reflects the specific lot produced. Ask which batch-specific documents are available for the quoted lot, including COA and supporting HPLC or MS records where applicable.
Documented before commitment
Ingredient identity (INCI / CAS), specification sheet, and SDS are available for technical review. Confirm documentation for the batch proposed for your order before purchase.
Documents Available
Documents Available
Spec
WUMO PDRN+™ Technical Data Sheet (TDS) & % INCI Breakdown
Request scope and availability through the B2B inquiry path.
Request this file through the inquiry path below.
Analytical File
Ex Vivo Porcine Raman, DLS & Preclinical Characterization Brief
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Request this analytical file through the inquiry path below.
COA
Batch Certificate of Analysis (COA) & 16-Section English GHS SDS
Batch-level quality summary for buyer-side file review.
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Overview
Overview
WUMO PDRN+™ (HCS@PDRN) addresses the main delivery bottleneck of topical salmon DNA cosmetics. Standard polydeoxyribonucleotide (Sodium DNA from Oncorhynchus mykiss or Oncorhynchus keta, 50–1,500 kDa) sits far above the 500 Da stratum corneum threshold and carries a strong negative charge (-32.9 ± 5.18 mV) that is repelled by cell membranes.
At a validated 6:1 carrier-to-PDRN mass ratio, positively charged amino groups on deacetylated Hydroxyethyl Chitosan condense anionic DNA chains into monodisperse 188.0 ± 4.32 nm nanospheres (PDI 0.14 ± 0.01). In third-party ex vivo porcine skin Raman spectroscopy, this co-assembly increased 4-hour cutaneous permeation by +494.44% compared with equal-dose free PDRN. Read the full WUMO PDRN+™ technical dossier →
Details
Details
How 6:1 Chitosan Co-Assembly Enables Transdermal & Cellular Uptake
- Stratum Corneum Bio-Adhesion: Cationic amino domains anchor the co-assembled complex onto negatively charged corneocytes instead of leaving a loose surface film that rubs off on fabric or applicators.
- Nanoscale Compression Across Skin Depth: Condensing hydrodynamic diameter from 539.5 nm to 188.0 nm (PDI 0.14; complete DNA binding verified in agarose gel Lane 7) supports transport through intercellular lipid pathways and hair follicles down to 20–120 μm depth.
- Fibroblast Macropinocytosis: Charge-shielded -16.1 mV nanospheres reduce membrane repulsion and enter dermal fibroblasts via macropinocytosis, verified by 4-hour Cy5/FITC dual-label colocalization.
- Endolysosomal Release & Carrier Biodegradation: Mildly acidic endolysosomes trigger protonation-driven swelling to release PDRN toward adenosine A2A receptors and the DNA salvage pathway, while glycoside hydrolases break the chitosan carrier down into endogenous D-glucosamine.
Preclinical Characterization vs. Equal-Dose Free PDRN
| Assay Model | Test Condition | Measured Gain vs. Free Unmodified PDRN |
|---|---|---|
| DLS & Gel Electrophoresis | 6:1 Hydroxyethyl Chitosan : PDRN co-assembly | Size 539.5 ± 20.42 nm → 188.0 ± 4.32 nm; PDI 0.53 → 0.14; Zeta -32.9 → -16.1 mV; Lane 7 complete complexation |
| Ex Vivo Porcine Skin Raman | 1.2% Carrier + 0.2% PDRN vs. 0.2% Free PDRN | +494.44% at 4 h (~6× faster entry), +213.77% at 8 h, +42.59% at 12 h across 20–120 μm skin depth |
| In Vivo Murine Dermal Fluorescence | 0.6% Carrier + 0.1% PDRN vs. 0.1% Free PDRN | +190% at 2 h and +260% at 8 h (p < 0.001) |
| HaCaT Cytokines, Scratch & EdU | 0.3% Carrier + 0.05% (500 ppm) PDRN vs. 0.05% Free PDRN (H2O2 injury) | Additional suppression: TNF-α -28.82%, IL-1β -23.96%, IL-6 -33.13%; 24 h residual scratch area -34.23%; EdU+ proliferation +22.91% |
| In Vivo DNFB Soothing Model | Low / Mid / High co-assembled groups vs. 0.029% (290 ppm) Free PDRN | Inflammatory epidermal thickening reduced by -20.11% / -38.38% / -52.26%; spleen index -6.64% / -16.85% / -25.15%; reduced mast-cell infiltration |
Literature & Scope Note: General adenosine A2A receptor and salvage-pathway pharmacology of salmon polydeoxyribonucleotide is reviewed in Squadrito et al., Front. Pharmacol. 2017 (DOI: 10.3389/fphar.2017.00224 ↗ · PMID: 28491036 ↗). The 6:1 HCS@PDRN Raman, DLS, and cellular datasets above are separate enterprise and third-party preclinical benchmarks conducted on this cosmetic raw material. Supplied for topical intact-skin cosmetic formulation only.
Related Peptides
Compare related ingredients without restarting the review.
Peptide Raw Materials
AHPX+ (Acetyl Hexapeptide-8 Pro) Chitosan Carrier Complex
Carrier-enhanced 1,000 ppm (0.1%) Acetyl Hexapeptide-8 aqueous cosmetic delivery complex paired with Suzhou Xilin’s patent-pending modified chitosan carrier (CN120248173A). Demonstrated +82% (2h) and +219% (8h) ex-vivo skin permeation vs. unmodified hexapeptide and 28-day human split-face substantiation (GQI, n = 33).
Patent-pending modified chitosan carrier (CN120248173A)+219% 8h ex-vivo skin uptake (3.19× vs. free peptide)28-day GQI split-face human study (n = 33)
Peptide Raw Materials
WUMO OatCalm+™ Supercritical Oat Alkaloid Complex (≥12% HPLC)
Water-soluble supercritical CO2 extracted (3.8× yield) and negative-charge-enriched Avena Sativa (Oat) Bran Extract standardized to ≥12% total oat alkaloids by HPLC (co-concentrating ≥7 natural avenanthramides A/B/C & caffeic acid derivatives), delivering >3× anti-inflammatory potency, TRPV1/PAR-2 neuro-calming, and Filaggrin/Claudin-1 barrier support.
≥12% HPLC total oat alkaloids (≥7 natural avenanthramides A, B, C + caffeic acid derivatives)3.8× extraction yield via supercritical CO2 + negative-charge-guided enrichment>3× in-vitro anti-inflammatory inhibition vs. conventional oat extract; blocks TRPV1 & PAR-2
Finished Formulation Concepts
One-Step Clear-Turning Salmon DNA (PDRN+) & Peptide Hydrogel Mask ODM
One-step milky-to-clear cast hydrogel mask ODM pairing AHPX+ (30 ppm), WUMO PDRN+™ (200 ppm), <0.5 EU/mL Type III Collagen & OatCalm+™.
Finished Formulation Concepts
Dual-Phase Peptide & Nano-PDRN Suspended Capsule Cream OEM/ODM
Suspended shear-burst peptide & nano-PDRN capsules in a soothing OatCalm+™ & <0.5 EU/mL Type III Collagen gel-cream for ISO 22716 OEM/ODM.
Cosmetic Pro-Peptide Delivery & Flexible ISO 22716 ODM
Developing a mid-to-high-end skincare or scalp SKU with WUMO PDRN+™ Transdermal Chitosan-PDRN Complex (6:1 HCS@PDRN)?
Compare neat raw actives, AHPX+ modified-chitosan delivery complex
(CN120248173A, +219% 8h skin permeation), bulk compounded
kg / liter semi-finished bases, and phased custom-packaged ODM at
Suzhou Xilin Technology Co., Ltd. (ISO 22716:2007 Cert. 27825-2025GPOC00009R000,
covering liquid & eye-care/cream scope): explore our Pro-Peptide Science & ODM Hub or Finished Skincare OEM / ODM Service.
Request WUMO PDRN+™ Transdermal Chitosan-PDRN Complex (6:1 HCS@PDRN) Batch COA, Sample, or Bulk / ODM Pricing
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