Explore Dual-PhD carrier research, patent-pending modified-chitosan delivery, and 4 flexible cosmetic ODM tracks.
Refractive-index homogenization shifts the cast hydrogel sheet from milky-white to transparent over 45–120 minutes as the aqueous active phase partitions into skin.
Refractive-index homogenization shifts the cast hydrogel sheet from milky-white to transparent over 45–120 minutes as the aqueous active phase partitions into skin.
One-Step Clear-Turning Salmon DNA (PDRN+) & Peptide Hydrogel Mask ODM
Cast biphasic hydrogel facial mask ODM architecture that shifts from opaque milky-white to transparent as hydrated actives absorb into skin. Pairs AHPX+ (30 ppm net active peptide), WUMO PDRN+™ (200 ppm), < 0.5 EU/mL Recombinant Humanized Type III Collagen, and WUMO OatCalm+™.
Milky-to-transparent optical shift driven by refractive-index homogenization during skin contactFour-active reference stack: AHPX+ (30 ppm active peptide) + PDRN+ (200 ppm) + <0.5 EU/mL Type III Collagen + OatCalm+™Non-dripping 2-piece contoured cast hydrogel suited for 45–120 min clinic or overnight wearSupported by EU CPSR/PIF, UK SCPN, US MoCRA & ANVISA manufacturer dossiers under NDA
Formulation Snapshot
Formulation Snapshot
FormatClear-Turning Hydrogel Mask
Key PeptideAHPX+ (30 ppm active hexapeptide) + WUMO PDRN+™ (200 ppm) + <0.5 EU/mL Recombinant Type III Collagen + OatCalm+™
Application DirectionOptical milky-to-clear transdermal firming & barrier-soothing hydrogel mask
Development StageValidated turnkey ODM architecture — ready for custom active tuning, gsm/mold selection & foil-sachet production
CustomizationMask sheet gsm (28–38 g), optical clearing window (45–120 min or overnight), active stack tuning (AHPX+, PDRN+, <0.5 EU/mL Type III Collagen, GHK-Cu, or Ectoin), and custom foil-pouch + carton packaging.
+219% 8-hour ex-vivo skin permeation, -32.0% ACh inhibition at 1/10th dose, and GQI 33-subject trial data.
Inspect on-site booth photos, ISO 22716:2007 cosmetic GMP certificate, and buyer Q&A from Guangzhou.
Applications
Application Direction
- Flagship 60-minute or overnight clear-turning collagen and salmon DNA hydrogel masks
- Dermatology and aesthetic clinic post-facial cooling comfort mask programs (intact-skin cosmetic scope)
- Clinical skincare brand launches requiring documented carrier permeation data
Documents Available
Documents Available
Spec
Suzhou Xilin ISO 22716:2007 Certificate (Cosmetics GMP Scope)
Request scope and availability through the B2B inquiry path.
Spec
Clear-Turning Hydrogel Architecture, <0.5 EU/mL Collagen QC & PIF/MoCRA Dossier Scope
Request scope and availability through the B2B inquiry path.
Request this file through the inquiry path below.
Overview
Overview
Unlike non-woven sheet masks that drip free serum, a One-Step Clear-Turning Hydrogel Mask is cast as an opaque milky-white biphasic gel. Micro-dispersed emollient droplets initially scatter light against the hydrated polymer network. Over 45–120 minutes on skin, the aqueous carrier phase partitions into the stratum corneum and equalizes the gel’s refractive index, turning the sheet transparent as transfer progresses.
Rather than pairing that hydrogel base with animal gelatin or unabsorbed 2,000 ppm free salmon DNA powder, WUMO combines four targeted modules: AHPX+ (30 ppm net active Acetyl Hexapeptide-8 via CN120248173A carrier), WUMO PDRN+™ (200 ppm 6:1 chitosan-condensed salmon DNA), Recombinant Humanized Type III Collagen controlled to bacterial endotoxin < 0.5 EU/mL (1,000 ppm reference), and WUMO OatCalm+™ (≥12% HPLC oat alkaloids).
Details
Details
Reference Four-Active Architecture Inside the Clear-Turning Matrix
| Formulation Module | Reference Target Spec | Formulation Advantage Over Standard Hydrogel Masks |
|---|---|---|
| 1. Transdermal Salmon DNA (WUMO PDRN+™) | 200 ppm co-assembled 6:1 HCS@PDRN (188.0 nm, PDI 0.14) |
Addresses the 50–1,500 kDa size and -32.9 mV charge barrier (+494.44% 4h porcine Raman permeation) rather than leaving free DNA on the surface |
| 2. Carrier Neuro-Peptide (AHPX+) | 3.0% complex = 30 ppm net active Acetyl Hexapeptide-8 | CN120248173A modified chitosan carrier achieved -32.0% ACh inhibition at 1/10th concentration and +219% 8h permeation |
| 3. Low-Endotoxin Type III Collagen | 1,000 ppm Recombinant Humanized Type III Collagen (< 0.5 EU/mL) | Avoids marine/animal odor, batch MW drift, and endotoxin-triggered flushing seen with commodity hydrolyzed collagen |
| 4. Neuro-Sensory Comfort (WUMO OatCalm+™) | 0.5%–1.5% (standardized ≥12% HPLC oat alkaloids) | Inhibits TRPV1 and PAR-2 stinging pathways while supporting Filaggrin and Claudin-1 during extended occlusive wear |
Scope Note: Supplied as a non-sterile topical cosmetic mask for intact-skin hydration, elasticity appearance, and barrier comfort. Bacterial endotoxin control (< 0.5 EU/mL) reflects raw-material purity selection for sensitive-skin cosmetics and does not imply sterile or injectable status.
Development Discussion Guide
Development Discussion Guide
1. Align Clearing Time & Active Stack on Bench Prototypes
Evaluate 45–90 minute clinic clearing versus overnight wear rheology alongside your preferred active ratios (PDRN+, AHPX+, Type III Collagen, or GHK-Cu).
2. Confirm Pouch Packaging & Export Regulatory Dossier
Review per-pouch bulk/filling structure, quantitative % INCI breakdown under NDA, and EU CPSR/PIF plus US MoCRA manufacturer files.
Related Peptides
Compare related ingredients without restarting the review.
Peptide Raw Materials
WUMO PDRN+™ Transdermal Chitosan-PDRN Complex (6:1 HCS@PDRN)
Electrostatic 6:1 hydroxyethyl-chitosan self-assembled transdermal salmon DNA (Sodium DNA / PDRN) delivery system compressing 539.5 nm free PDRN (PDI 0.53) into monodisperse 188.0 ± 4.32 nm nanospheres (PDI 0.14). Verified +494.44% 4-hour ex vivo porcine skin Raman permeation and +260% 8-hour in vivo dermal fluorescence.
+494.44% 4h ex vivo porcine skin Raman permeation (~6× faster barrier entry)539.5 nm (PDI 0.53) → 188.0 ± 4.32 nm (PDI 0.14) monodisperse 6:1 co-assembly+260% 8h in vivo dermal fluorescence (p < 0.001) & macropinocytosis uptake
Peptide Raw Materials
AHPX+ (Acetyl Hexapeptide-8 Pro) Chitosan Carrier Complex
Carrier-enhanced 1,000 ppm (0.1%) Acetyl Hexapeptide-8 aqueous cosmetic delivery complex paired with Suzhou Xilin’s patent-pending modified chitosan carrier (CN120248173A). Demonstrated +82% (2h) and +219% (8h) ex-vivo skin permeation vs. unmodified hexapeptide and 28-day human split-face substantiation (GQI, n = 33).
Patent-pending modified chitosan carrier (CN120248173A)+219% 8h ex-vivo skin uptake (3.19× vs. free peptide)28-day GQI split-face human study (n = 33)
Peptide Raw Materials
WUMO OatCalm+™ Supercritical Oat Alkaloid Complex (≥12% HPLC)
Water-soluble supercritical CO2 extracted (3.8× yield) and negative-charge-enriched Avena Sativa (Oat) Bran Extract standardized to ≥12% total oat alkaloids by HPLC (co-concentrating ≥7 natural avenanthramides A/B/C & caffeic acid derivatives), delivering >3× anti-inflammatory potency, TRPV1/PAR-2 neuro-calming, and Filaggrin/Claudin-1 barrier support.
≥12% HPLC total oat alkaloids (≥7 natural avenanthramides A, B, C + caffeic acid derivatives)3.8× extraction yield via supercritical CO2 + negative-charge-guided enrichment>3× in-vitro anti-inflammatory inhibition vs. conventional oat extract; blocks TRPV1 & PAR-2
Finished Formulation Concepts
Dual-Phase Peptide & Nano-PDRN Suspended Capsule Cream OEM/ODM
Suspended shear-burst peptide & nano-PDRN capsules in a soothing OatCalm+™ & <0.5 EU/mL Type III Collagen gel-cream for ISO 22716 OEM/ODM.
Cosmetic Pro-Peptide Delivery & Flexible ISO 22716 ODM
Developing a mid-to-high-end skincare or scalp SKU with One-Step Clear-Turning Salmon DNA (PDRN+) & Peptide Hydrogel Mask ODM?
Compare neat raw actives, AHPX+ modified-chitosan delivery complex
(CN120248173A, +219% 8h skin permeation), bulk compounded
kg / liter semi-finished bases, and phased custom-packaged ODM at
Suzhou Xilin Technology Co., Ltd. (ISO 22716:2007 Cert. 27825-2025GPOC00009R000,
covering liquid & eye-care/cream scope): explore our Pro-Peptide Science & ODM Hub or Finished Skincare OEM / ODM Service.
Request One-Step Clear-Turning Salmon DNA (PDRN+) & Peptide Hydrogel Mask ODM Benchmark Sample, Bulk Base, or Phased ODM Quote
Share your target format (raw active by g/kg, bulk semi-finished base by kg/liter, or custom-packaged ODM), target active %, and destination market (EU PIF/CPSR, UK SCPN, US MoCRA, ANVISA).